Tatarintsev A Makarova T Karamov E Kornilayeva G Vrzheshch P Schegolev A
Yershov D Turgiev A
Ajoene blocks HIV-mediated syncytia formation: possible approach to
'anti-adhesion' therapy of AIDS.
In: Int Conf AIDS (1992 Jul 19-24) 8(3):39 (abstract no. PuA 6173)
OBJECTIVES: Ajoene, (E, Z)-4, 5, 9-trithiadodeca-1, 6, 11-triene-9-oxide, isolated
from extracts of garlic (Allium sativum) has previously beenshown to inhibit
platelet aggregation by inactivating allostericallythe platelet integrin, GP
IIb/IIIa (Apitz-Castro R et al: BBRC 1986141:145). Structural and functional
similarity of integrins led us topropose that ajoene may also inhibit adhesive
interactions ofleukocytes. Since integrin-mediated formation of
cell-to-cellcontacts has been shown to be an essential prerequisite for
membranefusion (Hildreth JEK, Orentas RJ: Science 1989 244:1075) we
alsoattempted to evaluate